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Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including gastric cancer. However, the effect of Tanshinone IIA on gastric cancer cell stemness stays unclear. Here, we found that Tanshinone IIA could reduce gastric cancer cell stemness through detecting spheroid‐forming, flow...
Background
Recent studies and clinical samples have demonstrated that Helicobacter pylori could induce the downregulation of miR‐375 in the stomach and promote gastric carcinogenesis. However, whether the immune cells are affected by Helicobacter pylori due to the downregulation of miR‐375 is unclear.
Materials and methods
In this study, we constructed an overexpression and knockdown of miR‐375...