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Clustered, regularly interspaced, short palindromic repeats – CRISPR-associated (CRISPR-Cas) systems – are sequence-specific RNA-directed endonuclease complexes that bind and cleave nucleic acids. These systems evolved within prokaryotes as adaptive immune defenses to target and degrade nucleic acids derived from bacteriophages and other foreign genetic elements. The antiviral function of these systems...
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