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Plasma protein binding (PPB) can possibly alter the already variable pharmacokinetics of voriconazole. Voriconazole PPB was determined only once, being 58%, according to equilibrium dialysis (ED). We investigated voriconazole PPB more in detail, with a convenient and newer high‐throughput ED assay (HT‐ED), in human blank plasma spiked with voriconazole and in plasma from intensive care unit (ICU)...
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