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Background: We have previously shown that mildly oxidized low density lipoprotein (mox-LDL) induced vascular smooth muscle cell (VSMC) proliferation and this effect was potentiated by 5HT. We examined the possible mechanisms for these effects.Methods: Growth arrested primary rabbit VSMC were incubated with different concentrations of LDL or mox-LDL in the presence or absence of pertussis toxin (PTX,...
Background: Previous studies have shown that very low density, iso density and low density lipoproteins (VLDL, IDL and LDL) from hyperlipidemic plasma are more atherogenic than those from normal plasma. Since platelet aggregation at sites of atherosclerotic injury exposes the cells to high concentrations of serotonin (5HT), a known mitogen for vascular smooth muscle cells (VSMC), we examined whether...
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