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Biologic scaffolds composed of extracellular matrix (ECM) have been used to reinforce or replace damaged or missing musculotendinous tissues in both preclinical studies and in human clinical applications. However, most studies have focused upon morphologic endpoints and few studies have assessed the in-situ functionality of newly formed tissue; especially new skeletal muscle tissue. The objective...
Naturally occurring antibodies to the galactose α1,3 galactose (αgal) epitope expressed on xenogeneic grafts are a major barrier to organ transplantation in humans. Porcine small intestinal submucosa (SIS) expresses the αgal epitope and is currently being used as a bioscaffold for tissue remodeling. To examine in detail the potential role of the αgal epitope in immune recognition of this acellular,...
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