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Adducin (ADD) is a heterodimeric protein of the membrane skeleton with subunits of 103 (α) and 97 kDa (β). It promotes the assembly of the spectrin-actin network. We have previously shown that one point mutation in each of the α and β rat ADD-encoding genes is associated with blood pressure variation in an animal model for hypertension, the Milan hypertensive strain of rats, probably due to a change...
A polymorphism in the genes encoding α- and β-adducin (ADD) was described as being associated with blood-pressure variation in a genetically hypertensive strain of rats (MHS). ADD is a cytoskeletal heterodimeric protein which may be involved in cellular signal transduction and interacts with other membrane skeleton proteins which affect ion transport across the cell membrane. The cDNA encoding the...
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