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Calpain (CANP) is a calcium-activated protease present in two isoforms in the neuronal cells, CANP I and CANP II, with different sensitivities to calcium ions. Only CANP I is present in human erythrocytes. Its activity is naturally inhibited by calpastatin (CAST). It has been suggested that CANP and CAST are involved in the regulation of long term potentiation (LTP), the long-lasting enhancement...
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