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This study investigated the effects of intemittent hydrostatic pressure (IHP) patterns on the responses of mesenchymal stem cells (MSCs) such as osteogenic differentiation, proliferation and senescence. For these experimental groups were set based on IHP patterns: (1) C_BM: control group with no stimulation in basal media; (2) C_OM: control group with no stimulation in osteogenic media (OM); (3) S_2H/5M:...
Substrate stiffness and mechanical stimuli are known to play important roles in regulating differentiation of stem cells. However, most studies on this have adopted only one of those two factors while other factor is kept constant. In this study we have varied those two factors simultaneously to investigate the combinational effects focusing on osteogenic differentiation of menschymal stem cells (MSCs)...
In this study, we investigated the effects of combinational stimulation consisting of cyclic tension and intermittent hydrostatic pressure (IHP) on the differentiation of mesenchymal stem cells (MSCs) into osteoblasts without biochemical agents. For this, we designed a novel bioreactor which can engage tensile stimuli and IHP simultaneously. We classified experimental groups based on types of stimulation...
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