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ScopeThe basic dipeptide, Trp‐His, was found to show an in vivo anti‐atherosclerotic effect when orally administered to apo E‐deficient mice. In addition, this dipeptide causes vasorelaxation in contracted rat aorta via suppression of intracellular Ca2+ signaling cascades. In this study, we attempted to determine whether Trp‐His can be absorbed after single oral administration in Sprague–Dawley (SD)...
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