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Mesoporous silica nanoparticles (MSN) can load and deliver potentially synergistic anticancer agents such as small molecule cytotoxics (like doxorubicin, DOX) and nucleic acids (like microRNA, miRNA). However, these cargos have different underlying chemical properties so overcoming respective intracellular delivery barriers is a key consideration. Strategies to deliver DOX from MSN frequently employ...
In article number 1801118 Mei Zhao, Chao Fang, and co‐workers develop a smart mesoporous silica nanoparticles (MSN) based nanosystem for doxorubicin and microRNA‐145 co‐delivery (Dm@TMSN). By “weaving” polyethylenimine on the MSN surface through disulfide bonds the counter‐productive dilemma generated from intracellular compartment‐dependent delivery and release of both cargos is overcome. By integrating...
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