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In anticipation of the availability of next‐generation sequencing data, there is increasing interest in investigating association between complex traits and rare variants (RVs). In contrast to association studies for common variants (CVs), due to the low frequencies of RVs, common wisdom suggests that existing statistical tests for CVs might not work, motivating the recent development of several new...
In anticipation of the availability of next‐generation sequencing data, there has been increasing interest in association analysis of rare variants (RVs). Owing to the extremely low frequency of a RV, single variant‐based analysis and many existing tests developed for common variants may not be suitable. Hence, it is of interest to develop powerful statistical tests to assess association between complex...
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