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A sensitive, specific and highly reproducible method for the analysis of the two antineoplastics, ifosfamide and cyclophosphamide, in sewage water at the ppt-level is presented. The method includes a two-step solid-phase extraction (SPE) on C 18 and SiOH material and GC-MS analysis using single ion monitoring (SIM). The method was applied to degradational studies of the two drugs in...
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