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Catalase Nanocrystals
In article number 2103569, Tymish Y. Ohulchanskyy, and co‐authors introduce catalase protein nanocrystals as drug nanocarriers producing molecular oxygen within hypoxic tumors. A prolonged catalytic activity of the nanocrystals enables continuing reaction between catalase and endogenous H2O2, which generates oxygen, while the nanocrystal porosity allows for soaking with the photosensitizer...
Photodynamic therapy (PDT) is a well‐known method for cancer therapy in the clinic. However, the inherent hypoxia microenvironment of solid tumors enormously restricts the PDT efficiency. Herein, catalase nanocrystals (CatCry) are introduced as in situ oxygen (O2)‐generating system to relieve tumor hypoxia and enhance PDT efficiency for solid tumors. After loading with photosensitizer methylene blue...
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