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The progression and metastasis of solid tumors rely strongly on neovascularization. However, angiogenesis inhibitors alone cannot meet the needs of tumor therapy. This study prepared a new drug conjugate (PTX‐GSHP‐CYS‐ES2, PGCE) by combining polysaccharides (heparin without anticoagulant activity, GSHP), chemotherapeutic drugs (paclitaxel, PTX), and antiangiogenic drugs (ES2). Furthermore, a tumor‐targeted...
Single‐atom alloys (SAAs) display excellent electrocatalytic performance by overcoming the scaling relationships in alloys. However, due to the lack of a unique structure engineering design, it is difficult to obtain SAAs with a high specific surface area to expose more active sites. Herein, single Co atoms are immobilized on Pd metallene (Pdm) support to obtain Co/Pdm through the design of the engineered...
Near‐field radiative heat transfer (NFRHT) can exceed the blackbody radiation limit owing to the coupled evanescent waves, implying a significant potential for energy conversion and thermal management. Coupled surface plasmon polaritons (SPPs) and hyperbolic phonon polaritons (HPPs) with small ohmic losses enable a long propagation wavelength that is essential in NFRHT. However, so far, there still...
Radiative Heat Transfer
In article number 2108032, Jinlin Song, Zixue Luo, Qiang Cheng, and co‐workers measure the near‐field radiative heat transfer between graphene/hexagonal boron nitride systems, where the coupling of hyperbolic phonon polaritons and surface plasmon polaritons is examined. The largest ever radiative heat flux is achieved for a gap space of ≈400 nm, which is six times higher than...
Atherosclerosis Treatment
Herb derived drugs modulate gut microbiome homeostasis and gut‐generated bio‐metabolites. In article number 2105021, Jian‐Dong Jiang, Yongsheng Che, Lu‐Lu Wang, and co‐workers modify the immune cell dynamics and liver function using herb‐derived bicyclol, leading to improved chronic inflammation and cholesterol metabolism. The endothelial activation and cholesterol ester...
Atherosclerosis (AS) is associated with high morbidity and mortality, thus imposing a growing burden on modern society. Herb‐derived bicyclol (BIC) is a versatile bioactive compound that can be used to treat AS. However, its efficacy in AS is not yet described. Here, it is shown that BIC normalizes gut microflora dysbiosis induced by a high fat diet in Apoe(−/−) mice. Metagenome‐wide association study...
In vivo fluorescence imaging can perform real‐time, noninvasive, and high spatiotemporal resolution imaging to accurately obtain the dynamic biological information in vivo, which plays significant roles in the early diagnosis and treatment of cancer. However, traditional in vivo fluorescence imaging usually operates in the visible and near‐infrared (NIR)‐I windows, which are severely interfered by...
Many enveloped viruses utilize endocytic pathways and vesicle trafficking to infect host cells, where the acidification of virus‐containing endosomes triggers the virus‐endosome fusion events. Therefore, simultaneous correlation of intracellular location, local pH, and individual virus dynamics is important for gaining insight into viral infection mechanisms. Here, an imaging approach is developed...
Liver tumor is difficult to cure for its high degree of malignancy and rapid progression characteristics. Ferroptosis as a new model of inducing cell death is expected to break the treatment bottleneck of liver tumors. Here, a strategy to induce ferroptosis in HepG2 cells with acid‐degradable tumor targeted nanosheets Cu‐Hemin‐PEG‐Lactose acid (Cu‐Hemin‐PEG‐LA) is proposed. After highly ingested by...
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