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Increasing evidence has demonstrated that Toll‐like receptor 4 (TLR4) ‐mediated systemic inflammatory response syndrome accompanied by multiple organ failure, is one of the most common causes of death in patients with severe acute pancreatitis. Recent reports have revealed that heparan sulphate (HS) proteoglycan, a component of extracellular matrices, potentiates the activation of intracellular pro‐inflammatory...
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