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Halichoblelide B (1) and C (2), novel macrolides with potent cytotoxicity against tumor cells in culture, have been isolated from a strain of Streptomyces hygroscopicus originally derived from the marine fish Halichoeres bleekeri, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and chemical transformations. These compounds...
Halichoblelide, a novel macrolide with potent cytotoxicity against tumour cells in culture, has been isolated from a strain of Streptomyces hygroscopicus originally separated from the marine fish Halichoeres bleekeri, and the absolute stereostructure has been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and some chemical transformations.
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