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The frequently dysregulated Wnt/β‐catenin signaling in different malignancies, by activation of its own or orchestration with other co‐factors, regulates various oncogenic or tumor‐suppressive genes. Among these genes, miRNAs, which are negative posttranscriptional regulators, are also embedded in the Wnt signaling network. Different from the Wnt‐induced oncogenic miRNAs, the specific mechanism underlying...
The L‐plastin gene is involved in the invasion and metastasis of prostate cancer. However, the molecular mechanisms underlying L‐plastin transcription are unclear. We hypothesize that the occurrence of polymorphic genetic variations in the L‐plastin promoter might affect an individual's susceptibility to prostate cancer. In this study, we identified a single nucleotide polymorphism (SNP) at position...
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