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Aim
Interleukin (IL) 1 receptor‐like 1, encoded by the IL1RL1 gene, is a receptor for IL‐33. In European birth cohorts, IL1RL1 rs102082293, rs10204137 (rs4988955), rs13424006 and rs13431828 (rs13048661) variations were associated with asthma at school age. In a Dutch multi‐centre study, IL1RL1 rs1921622 variation was associated with severe bronchiolitis. We evaluated the associations of these five...
Background
Toll‐interacting protein is a key factor in regulating innate immunity responses via gatekeeping Toll‐like receptors. Genetic variance in innate immunity has been linked with susceptibility to infections. Children with viral bronchiolitis in infancy are at increased risk of later asthma. The aim was to evaluate the role of toll‐interacting protein gene point mutations in severity of bronchiolitis...