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The interplay between neutrophils and endothelial cells allows ANCA to become pathogenic and results in uncontrolled inflammation in the vessel wall. This review presents an overall view on neutrophil–endothelial interaction during inflammation with a focus on ANCA-associated vasculitis, and summarizes the effector mechanisms which cause vascular damage in AAV. In addition, potential elements for...
Wegener's Granulomatosis (WG) is a life-threatening autoimmune disease. A pathogenic role for anti-neutrophil cytoplasmic autoantibodies (ANCAs) by inducing necrotizing damage to the vessel wall has been strongly suggested by in vitro and in vivo experimental data. Proteinase 3 (PR3), a serine protease mainly stored in the azurophilic granules of neutrophils, has been identified as a major ANCA-antigen...
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