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BackgroundPrevious study demonstrated that overstimulation of TRPM7 substantially contributes to zinc‐mediated neuronal toxicity. Inhibition of TRPM7 activity and TRPM7‐mediated intracellular Zn2+ accumulation may represent a promising strategy in the treatment of stroke.
AimsTo investigate whether local anesthetics lidocaine could inhibit TRPM7 channel and TRPM7‐mediated zinc toxicity.
MethodsWhole‐cell...
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