Search results for: Chandana Haldar

Items from 1 to 20 out of 48 results

article

Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC‐α/Akt pathway in female golden hamster: Involvement of altered Aanat and Bmal1 rhythm

Megha Das, Chandana Haldar, Sanjeev Kumar Yadav

Journal of Pineal Research > 75 > 2 > n/a - n/a

Female night‐workers get exposed to frequent light shifts, hence have altered circadian rhythm and are at high risk of endometrial cancer; the underlying mechanism however is still not clear. We, therefore examined the effect of long light exposure (16L:8D, LD1) and regular shift (8 h) in long nighttime (LD2) on endometrial changes of female golden hamsters. Morphometric analysis, scanning electron...

article

BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster

Sriparna Pal, Aishwarya Sahu, Rakesh Verma, Chandana Haldar

Journal of Pineal Research > 75 > 1 > n/a - n/a

Ever‐increasing occurrence of plastic‐manufacturing industries leads to environmental pollution that has been associated with declined human health and increased incidence of compromised reproductive health. Female subfertility/infertility is a complex phenomenon and environmental toxicants as well as lifestyle factors have a crucial role to play. Bisphenol S (BPS) was believed to be a “safer” replacement...

article

Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf‐2/HO‐1 and SIRT‐1/FOXO‐1 expressions

Jitendra Kumar, Rakesh Verma, Chandana Haldar

Environmental Toxicology > 36 > 3 > 396 - 407

BPS has detrimental effects on human reproductive health and emerged as an environmental contaminant for global health concern. This study deals with the adverse impact of BPS exposure on testicular oxidative stress, inflammation and apoptosis in adult male golden hamster, Mesocricetus auratus and its amelioration by melatonin. BPS (75 mg/kg BW/day) exposure caused testicular impairment as evident...

article

Trade‐off expression of melatonin receptor subtypes (Mel1a and Mel1b) and androgen receptor in lung of a tropical bird, Perdicula asiatica

Rajesh Kumar Kharwar, Vaishali Singh, Chandana Haldar

Anatomia, Histologia, Embryologia > 49 > 4 > 457 - 463

The role of circulatory steroid hormone along with melatonin in lung of any seasonally breeding bird has never been explored so far. This could be interesting because steroid hormones are immunosuppressive while melatonin is immunostimulatory in nature. In our present study, we report the effect of exogenous melatonin and testosterone on expression of melatonin receptor subtypes (Mel_1a and Mel_1b)...

article

Short day length enhances physiological resilience of the immune system against 2-deoxy-d-glucose-induced metabolic stress in a tropical seasonal breeder Funambulus pennanti

Sameer Gupta, Chandana Haldar

Hormones and Behavior > 2017 > 89 > C > 157-166

Studies demonstrate the importance of metabolic resources in the regulation of reproduction and immune functions in seasonal breeders. In this regard, the restricted energy availability can be considered as an environmental variable that may act as a seasonal stressor and can lead to compromised immune functions. The present study explored the effect of photoperiodic variation in the regulation of...

article

Effect of Naltrexone on photoperiodic regulation of testicular steroidogenesis in adult golden hamster, Mesocricetus auratus

Arun Mukherjee, Chandana Haldar

General and Comparative Endocrinology > 2016 > 239 > C > 89-96

Photoperiodic regulation of testicular steroidogenesis through modulation of MT1R expression and local melatonin content is well established. However, additional mediators besides local melatonergic system in photoperiodic control of testicular steroidogenesis in golden hamster have not been studied in detail. Endogenous opioid peptides (EOP) are known to regulate reproduction via acting at multiple...

article

Photoperiodic modulation of local melatonin synthesis and its role in regulation of thymic homeostasis in Funambulus pennanti

Sameer Gupta, Chandana Haldar

General and Comparative Endocrinology > 2016 > 239 > C > 40-49

The effect of photo-neuroendocrine system on the thymic (immune) functions is mediated by gonadal steroid and the pineal hormone melatonin. The present study explored the effect of photoperiod on the thymic melatonergic system and its role in protection of thymic T-cells from the testosterone induced seasonal oxidative stress and apoptosis. Exposure to long day-length (LD) was noted to decrease local...

article

Photoperiodic modulation of thyroid hormone receptor (TR-α), deiodinase-2 (Dio-2) and glucose transporters (GLUT 1 and GLUT 4) expression in testis of adult golden hamster, Mesocricetus auratus

Rakesh Verma, Chandana Haldar

Journal of Photochemistry and Photobiology B: Biology > 2016 > 165 > C > 351-358

Phenomenon of seasonal reproduction is being regulated by changes in day length or photoperiod. The molecular mechanism underlying the event of photoperiodic regulation of testis and thyroid functions along with glucose uptake transporters has never been reported for golden hamster, M. auratus. The present study was performed to investigate the effect of photoperiod on the expression of key thyroid...

article

Melatonin modulates glucocorticoid receptor mediated inhibition of antioxidant response and apoptosis in peripheral blood mononuclear cells

Amaresh Kumar Singh, Chandana Haldar

Molecular and Cellular Endocrinology > 2016 > 436 > C > 59-67

Pineal melatonin is known for its immunomodulatory and anti-stress properties. It modulates stress condition by regulating antioxidant responses and apoptosis in the immune cells. Stress causes increased glucocorticoid level that acts through glucocorticoid receptor (GR) and is translocated into nucleus under regulation of HSP90 based chaperone machinery. Melatonin influences glucocorticoid and GR...

article

Melatonin alleviates hyperthyroidism induced oxidative stress and neuronal cell death in hippocampus of aged female golden hamster, Mesocricetus auratus

Geeta Rao, Rakesh Verma, Arun Mukherjee, Chandana Haldar, more

Experimental Gerontology > 2016 > 82 > C > 125-130

Oxidative stress is a well known phenomenon under hyperthyroid condition that induces various physiological and neural problems with a higher prevalence in females. We, therefore investigated the antioxidant potential of melatonin (Mel) on hyperthyroidism-induced oxidative stress and neuronal cell death in the hippocampus region of brain (cognition and memory centre) of aged female golden hamster,...

article

Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles

Sanjeev K. Pandey, Dinesh K. Patel, Akhilendra K. Maurya, Ravi Thakur, more

International Journal of Biological Macromolecules > 2016 > 89 > C > 99-110

Tamoxifen (Tmx) embedded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (PLGA-Tmx) is prepared to evaluate its better DNA cleavage potential, cytotoxicity using Dalton’s lymphoma ascite (DLA) cells and MDA-MB231 breast cancer cells. PLGA-Tmx nanoparticles are prepared through emulsified nanoprecipitation technique with varying dimension of 17–30nm by changing the concentrations of polymer, emulsifier...

article

Ambient UV-B exposure reduces the binding of ofloxacin with bacterial DNA gyrase and induces DNA damage mediated apoptosis

Jyoti Singh, Ashish Dwivedi, Syed Faiz Mujtaba, Krishna P. Singh, more

The International Journal of Biochemistry & Cell Biology > 2016 > 73 > C > 111-126

Ofloxacin (OFLX) is a broad spectrum antibiotic, which generates photo-products under sunlight exposure. Previous studies have failed to explain the attenuated anti-bacterial activity of OFLX. The study was extended to explore the unknown molecular mechanism of photogenotoxicity on human skin cell line (HaCaT) under environmental UV-B irradiation. Photochemically OFLX generates ROS and caused 2′-dGuO...

article

Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: An overview

Soumik Goswami, Chandana Haldar

Journal of Photochemistry and Photobiology B: Biology > 2015 > 153 > C > 281-288

The sun rays brings along the ultraviolet radiations (UVRs) which prove deleterious for living organisms. The UVR is a known mutagen and is the prime cause of skin carcinomas. UVR causes acute oxidative stress and this in turn deteriorates other physiological functions. Inflammatory conditions and elevation of pro-inflammatory molecules are also associated with UVR mediated cellular damages. The inflammatory...

article

Effect of 2-deoxy-d-glucose induced metabolic stress on testicular steroidogenesis and antioxidant status in golden hamster,Mesocricetus auratus: Role of photoperiod.

Arun Mukherjee, Chandana Haldar

Journal of Photochemistry and Photobiology B: Biology > 2015 > 153 > C > 40-50

The driving force underlying the evolution of reproductive seasonality is the marked seasonal fluctuation in energy availability. It is well established that photoperiod regulates testicular steroidogenesis through modulation of circulatory and local melatonin levels and MT1R expression in golden hamster. However, photoperiodic variation in energy availability and its impact on testicular steroidogenesis...

article

Melatonin prevents dexamethasone‐induced testicular oxidative stress and germ cell apoptosis in golden hamster, Mesocricetus auratus

Arun Mukherjee, Chandana Haldar, Dipanshu Kumar Vishwas

Andrologia > 47 > 8 > 920 - 931

This study investigated the protective effect of melatonin on dexamethasone (Dex), an extensively used anti‐inflammatory and immunosuppressive synthetic glucocorticoid, induced testicular oxidative stress and germ cell apoptosis in golden hamster. Hamsters were randomly divided into four groups (n = 7): group I – control; group II – melatonin treated (10 mg kg⁻¹ day⁻¹); group III – Dex treated (7 mg kg...

article

Melatonin membrane receptor (MT1R) expression and nitro-oxidative stress in testis of golden hamster, Mesocricetus auratus: An age-dependent study

Arun Mukherjee, Chandana Haldar

Experimental Gerontology > 2015 > 69 > C > 211-220

Age-dependent decline in melatonin level induces nitro-oxidative stress that compromises physiological homeostasis including reproduction. However, less information exist regarding the age-dependent variation in local melatonin (lMel) concentration and MT1R expression in testis and its interaction with testicular steroidogenesis and nitro-oxidative stress in golden hamster, Mesocricetus auratus. Therefore,...

article

Anti-cancer evaluation of quercetin embedded PLA nanoparticles synthesized by emulsified nanoprecipitation

Sanjeev K. Pandey, Dinesh K. Patel, Ravi Thakur, Durga P. Mishra, more

International Journal of Biological Macromolecules > 2015 > 75 > Complete > 521-529

This study was carried out to synthesize quercetin (Qt) embedded poly(lactic acid) (PLA) nanoparticles (PLA–Qt) and to evaluate anti-cancer efficacy of PLA–Qt by using human breast cancer cells. PLA–Qt were synthesized by using novel emulsified nanoprecipitation technique with varying dimension of 32±8 to 152±9nm of PLA–Qt with 62±3% (w/w) entrapment efficiency by varying the concentration of polymer,...

article

Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer

Sanjeev K. Pandey, Somenath Ghosh, Pralay Maiti, Chandana Haldar

International Journal of Biological Macromolecules > 2015 > 72 > C > 309-319

This study was carried out to assess the therapeutic efficacy and toxicity of tamoxifen (Tmx) loaded poly(d,l-lactic acid) (PLA) nanoparticles (Tmx-NPs) for breast cancer. An in vivo study was conducted to determine the effect of Tmx-NPs on DMBA induced mammary tumor in female Wistar rat. The experimental results showed that the mean diameter of Tmx-NPs was 224±3nm with 68±2% (w/w) of entrapment efficiency...

article

Me1_1b receptor mediated action of melatonin in regulation of lung associated immune system (LAIS) of Perdicula asiatica: An in vitro study

Rajesh Kumar Kharwar, Chandana Haldar, Sweta Singh

Biologia > 2015 > 70 > 11 > 1537-1544

The pineal hormone melatonin plays an important role in immunomodulation of avian species. These immunomodulatory effects of melatonin are known to be mediated by three membrane bound receptors found in birds, Mel_1a, Mel_1b and Mel_1c. However, specific involvement of these receptors in mediating immunomodulatory effects of melatonin in Lung Associated Immune System (LAIS) remains unexplored till date...

article

Human pineal gland: Histomorphological study in different age groups and different causes of death

Royana Singh, Somenath Ghosh, Abhinav Joshi, Chandana Haldar

Journal of the Anatomical Society of India > 2014 > 63 > 2 > 98-102

In human, the age dependent changes in the micro-anatomy and histology of different organs are most prevalent along with causes of death. As pineal is a neuro-endocrine gland and is target of various hormones of physiological importance hence, the effect of age and different unnatural causes of death may affect its histology. This aspect of histomorphology has never been studied previously. Therefore,...

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INFONA - science communication portal

Search results for: Chandana Haldar

Shift and longtime light induces endometrioid adenocarcinoma via activation of PKC‐α/Akt pathway in female golden hamster: Involvement of altered Aanat and Bmal1 rhythm

BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster

Melatonin ameliorates Bisphenol S induced testicular damages by modulating Nrf‐2/HO‐1 and SIRT‐1/FOXO‐1 expressions

Trade‐off expression of melatonin receptor subtypes (Mel1a and Mel1b) and androgen receptor in lung of a tropical bird, Perdicula asiatica

Short day length enhances physiological resilience of the immune system against 2-deoxy-d-glucose-induced metabolic stress in a tropical seasonal breeder Funambulus pennanti

Effect of Naltrexone on photoperiodic regulation of testicular steroidogenesis in adult golden hamster, Mesocricetus auratus

Photoperiodic modulation of local melatonin synthesis and its role in regulation of thymic homeostasis in Funambulus pennanti

Photoperiodic modulation of thyroid hormone receptor (TR-α), deiodinase-2 (Dio-2) and glucose transporters (GLUT 1 and GLUT 4) expression in testis of adult golden hamster, Mesocricetus auratus

Melatonin modulates glucocorticoid receptor mediated inhibition of antioxidant response and apoptosis in peripheral blood mononuclear cells

Melatonin alleviates hyperthyroidism induced oxidative stress and neuronal cell death in hippocampus of aged female golden hamster, Mesocricetus auratus

Controlled release of drug and better bioavailability using poly(lactic acid-co-glycolic acid) nanoparticles

Ambient UV-B exposure reduces the binding of ofloxacin with bacterial DNA gyrase and induces DNA damage mediated apoptosis

Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: An overview

Effect of 2-deoxy-d-glucose induced metabolic stress on testicular steroidogenesis and antioxidant status in golden hamster,Mesocricetus auratus: Role of photoperiod.

Melatonin prevents dexamethasone‐induced testicular oxidative stress and germ cell apoptosis in golden hamster, Mesocricetus auratus

Melatonin membrane receptor (MT1R) expression and nitro-oxidative stress in testis of golden hamster, Mesocricetus auratus: An age-dependent study

Anti-cancer evaluation of quercetin embedded PLA nanoparticles synthesized by emulsified nanoprecipitation

Therapeutic efficacy and toxicity of tamoxifen loaded PLA nanoparticles for breast cancer

Me1_1b receptor mediated action of melatonin in regulation of lung associated immune system (LAIS) of Perdicula asiatica: An in vitro study

Human pineal gland: Histomorphological study in different age groups and different causes of death

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