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The extracellular pH (pHe) of solid tumors is acidic, and there is evidence that an acidic pHe is related to invasiveness. Herein, we describe an MRI single‐infusion method to measure pHe in gliomas using a cocktail of contrast agents (CAs). The cocktail contained gadolinium–1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraaminophosphonate (GdDOTA‐4AmP) and dysprosium–1,4,7,10‐tetraazacyclododecane‐N,...
Metastasis is a multistep process that culminates in the spread of cells from a primary tumor to a distant site or organs. For tumor cells to be able to metastasize, they have to locally invade through basement membrane into the lymphatic and the blood vasculatures. Eventually they extravasate from the blood and colonize in the secondary organ. This process involves multiple interactions between the...
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