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Leptin is a pluripotent regulatory protein secreted by fat and exerts many effects through the CNS. Interpretation of the characteristics by which it crosses the blood–brain barrier (BBB) supports the view that leptin most potently signals the brain at serum levels well below those associated with the current definition of ideal body weight. This fits with the perspective that low serum levels of...
Recent studies have suggested a role for nitric oxide in the regulation of food intake. Neuropeptide Y (NPY) is one of the most potent orexigenic agents. Chronic administration of leptin decreases food intake. This study examined the effects of NPY and leptin on nitric oxide synthase (NOS) in the hypothalamus. Previously it has been demonstrated that obese (ob/ob) mice have elevated NOS levels in...
BARTNESS, T. J., J. E. MORLEY AND A. S. LEVINE. Effects of food deprivation and metabolic fuel utilization on the photoperiodic control of food intake in Siberian hamsters. PHYSIOL BEHAV 57(1) 61-68, 1995.--Unlike rats, Siberian hamsters exhibit seasonal changes in energy balance that are controlled by the photoperiod (daylength). In Siberian hamsters, body weight and fat, and food intake peak...
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