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Visceral leishmaniasis (VL) is a serious and widespread parasitic disease caused by Leishmania donovani complex. The threat of this fatal disease continues due to the lack of ideal drugs or vaccines. In this study, we selected Amastin, CaNA2, Kmp-11 and PDI proteins of Leishmania donovani for study, which are VL vaccine candidates or possible drug targets. Eleven bioinformatics tools were used to...
In the post-genome era, disease-relevant gene finding and prioritization have focused on genome-wide association studies and molecular interaction networks, due to their power in characterizing the functions of genes/proteins in genomics and network biology contexts. In this paper, we describe a simple yet generic computational framework based on protein interaction networks to perform and evaluate...
The identification of transcription factor binding sites in promoter sequences is an important problem, since it reveals information about the transcription regulation of genes. In this paper, a novel motif discovery method based on motif clustering and matching is proposed. Against a precompiled library of motifs which is represented by position weight matrices(PWMs), each L-mer in the dataset is...
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