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A sialoglycoprotein was isolated from the eggs of Carassius auratus (Ca-SGP) and its anti-osteoporotic activities were first investigated in in vitro and in vivo systems. In vitro experiments using osteoclast precursors showed that Ca-SGP significantly decreased the formation of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated osteoclasts, bone resorption pits and the expression...
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