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Fluorescence‐activated cell sorting (FACS)–purified pro‐B cells from fetal liver and adult bone marrow generate B cells with distinct phenotypes: fetal cells generate few IgDhigh B cells and half express CD5, whereas adult cells generate mostly IgDhigh cells and few express CD5. These results led us to propose a model of a developmental switch in B lymphopoiesis, similar to the well‐known switch in...
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