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Background
The St Jude Global Academy Neuro‐Oncology Training Seminar (NOTS) is a hybrid course in pediatric neuro‐oncology specifically designed for physicians from low‐income and middle‐income countries.
Methods
The curriculum for the course was created by conducting a targeted needs assessment that evaluated 11 domains of care for children with central nervous system (CNS) tumors. The targeted...
Background
Low‐grade gliomas (LGGs) and low‐grade glioneuronal tumors (LGGNTs) diagnosed during the first year of life carry unique clinical characteristics and challenges in management. However, data on the treatment burden, outcomes, and morbidities are lacking.
Methods
A retrospective study of LGGs and LGGNTs diagnosed in patients younger than 12 months at St. Jude Children’s Research Hospital...
BACKGROUNDRetinoblastoma has a 5‐year survival rate exceeding 95%, yet little is known about long‐term functional outcomes for these patients.
METHODSSixty‐nine adult survivors of retinoblastoma (mean age, 33 years; mean years post‐diagnosis, 31) who had enrolled in the St. Jude Lifetime Cohort Study completed clinical cognitive evaluations and questionnaires assessing adult social attainment. Scores...
BACKGROUND:New, effective chemotherapeutic agents are needed for intraocular retinoblastoma.
METHODS:This institutional clinical trial sought to estimate the rate of response to 2 courses of vincristine and topotecan (VT) window therapy in patients with bilateral retinoblastoma and advanced disease (Reese‐Ellsworth group IV or V) in at least 1 eye. The topotecan dose started at 3 mg/m2/day for 5...
BACKGROUND:Dysembryoplastic neuroepithelial tumors (DNETs) are benign glioneuronal tumors that occur in children. These tumors are characterized by seizures, lack of neurologic deficits, and a seemingly benign course after resection.
METHODS:A retrospective review was conducted of data relating to 11 children diagnosed with DNETs between January 1988 and December 2007 at St. Jude Children's Research...
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