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Hepatitis B virus (HBV) is the main etiological agent of hepatocellular carcinoma (HCC) worldwide. It has been classified into nine genotypes and several subgenotypes, with uneven global distribution. There is growing evidence that the viral genotype influences the course and outcome of chronic hepatitis B infection. Two evolutionarily different clusters of the subgenotype F1b, called basal and cosmopolitan,...
The genotype F (HBV‐F) is an autochthonous Native American strain of the hepatitis B virus. In this study, we reconstruct the HBV‐F long‐term evolution under a hypothesis of co‐divergence with humans in Central and South America, since their entry into the region 14.5‐16 thousand years ago. The Bayesian phylogeographic reconstruction supported a virus‐host co‐expansion; however, two evolutionary scenarios...
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