Search results for: Lyle C. Gurrin

Items from 1 to 20 out of 55 results

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Adiposity and estrogen receptor‐positive, postmenopausal breast cancer risk: Quantification of the mediating effects of fasting insulin and free estradiol

S. Ghazaleh Dashti, Julie A. Simpson, Amalia Karahalios, Vivian Viallon, more

International Journal of Cancer > 146 > 6 > 1541 - 1552

Adiposity increases estrogen receptor (ER)‐positive postmenopausal breast cancer risk. While mechanisms underlying this relationship are uncertain, dysregulated sex‐steroid hormone production and insulin signaling are likely pathways. Our aim was to quantify mediating effects of fasting insulin and free estradiol in the adiposity and ER‐positive postmenopausal breast cancer association. We used data...

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Effect decomposition through multiple causally nonordered mediators in the presence of exposure‐induced mediator‐outcome confounding

Murthy N. Mittinty, John W. Lynch, Andrew B. Forbes, Lyle C. Gurrin

Statistics in Medicine > 38 > 26 > 5085 - 5102

Avin et al (2005) showed that, in the presence of exposure‐induced mediator‐outcome confounding, decomposing the total causal effect (TCE) using standard conditional exchangeability assumptions is not possible even under a nonparametric structural equation model with all confounders observed. Subsequent research has investigated the assumptions required for such a decomposition to be identifiable...

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Early‐life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization

Melisa Y. Z. Lau, Shyamali C. Dharmage, John A. Burgess, Aung K. Win, more

Clinical & Experimental Allergy > 49 > 3 > 331 - 340

Background Markers of microbial exposure are thought to be associated with risk of allergic sensitization; however, the associations are inconsistent and may be related to gene‐environment interactions. Objective To examine the relationship between polymorphisms in the CD14 gene and allergic sensitization and whether sibling exposure, as a marker of microbial exposure, modified this relationship...

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Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNuts

Thanh D. Dang, Rachel L. Peters, Jennifer J. Koplin, Shyamali C. Dharmage, more

Allergy > 74 > 2 > 318 - 326

Background IgE‐mediated egg allergy presents as one of the most common food allergies in children. Measurement of egg white specific IgE (sIgE) levels in serum or skin prick test has been shown to be a poor predictor of clinical allergy to raw egg white, and also to baked or cooked egg. Recent developments in component resolved diagnostic (CRD) technology have enabled us to improve the way in which...

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Childhood measles contributes to post‐bronchodilator airflow obstruction in middle‐aged adults: A cohort study

Jennifer L. Perret, Melanie C. Matheson, Lyle C. Gurrin, David P. Johns, more

Respirology > 23 > 8 > 780 - 787

Background and objective Chronic obstructive pulmonary disease (COPD) has potential origins in childhood but an association between childhood measles and post‐bronchodilator (BD) airflow obstruction (AO) has not yet been shown. We investigated whether childhood measles contributed to post‐BD AO through interactions with asthma and/or smoking in a non‐immunized middle‐aged population. Methods The...

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Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review

Xin Dai, Gayan Bowatte, Adrian J. Lowe, Melanie C. Matheson, more

Current Allergy and Asthma Reports > 2018 > 18 > 3 > 1-15

Purpose of Review Glutathione S-transferase (GST) genes are involved in oxidative stress management and may modify the impact of indoor air pollution. We aimed to assess the influence of GST genes on the relationship between indoor air pollution and allergy/lung function. Recent Findings Our systematic review identified 22 eligible studies, with 15 supporting a gene-environment interaction. Carriers...

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Prevalence of clinic-defined food allergy in early adolescence: The SchoolNuts study

Mari Sasaki, Jennifer J. Koplin, Shyamali C. Dharmage, Michael J. Field, more

Journal of Allergy and Clinical Immunology > 2018 > 141 > 1 > 391-398.e4

Rising rates of food-induced anaphylaxis have recently been shown in the adolescent age group, following earlier descriptions of a rise in children younger than 5 years. However, few population-based studies have examined the prevalence of food allergy in adolescence using objective measures such as oral food challenge (OFC).We sought to determine the prevalence of food allergy among a population-based...

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The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up

Rachel L. Peters, Jennifer J. Koplin, Lyle C. Gurrin, Shyamali C. Dharmage, more

Journal of Allergy and Clinical Immunology > 2017 > 140 > 1 > 145-153.e8

The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse.This study aimed to report the updated prevalence of food allergy at age 1 year from the whole...

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Age at onset and persistence of eczema are related to subsequent risk of asthma and hay fever from birth to 18 years of age

Adrian J. Lowe, Bianca Angelica, John Su, Caroline J. Lodge, more

Pediatric Allergy and Immunology > 28 > 4 > 384 - 390

Background Few studies have simultaneously addressed the importance of age of onset and persistence of eczema for the subsequent development of asthma and hay fever, particularly into early adulthood. Methods A high‐risk birth cohort was recruited comprising 620 infants, who were then followed up frequently until 2 years of age, annually from age 3 to 7, then at 12 and 18 years, to document any...

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Peanut Allergen Threshold Study (PATS): Novel single-dose oral food challenge study to validate eliciting doses in children with peanut allergy

Jonathan O'B. Hourihane, Katrina J. Allen, Wayne G. Shreffler, Gillian Dunngalvin, more

Journal of Allergy and Clinical Immunology > 2017 > 139 > 5 > 1583-1590

Eliciting doses (EDs) of allergenic foods can be defined by the distribution of threshold doses for subjects within a specific population. The ED₀₅ is the dose that elicits a reaction in 5% of allergic subjects. The predicted ED₀₅ for peanut is 1.5 mg of peanut protein (6 mg of whole peanut).We sought to validate the predicted peanut ED₀₅ (1.5 mg) with a novel single-dose challenge.Consecutive eligible...

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HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype‐stratified cohort study of hemochromatosis in Australian women

Charles D Warne, Sophie G Zaloumis, Nadine A Bertalli, Martin B Delatycki, more

Journal of Gastroenterology and Hepatology > 32 > 4 > 797 - 802

Background and Aim Women who are homozygous for the p.C282Y mutation in the HFE gene are at much lower risk of iron overload‐related disease than p.C282Y homozygous men, presumably because of the iron‐depleting effects of menstruation and pregnancy. We used data from a population cohort study to model the impact of menstruation cessation at menopause on serum ferritin (SF) levels in female p.C282Y...

article

GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes

James C. Barton, Wen-pin Chen, Mary J. Emond, Pradyumna D. Phatak, more

Blood Cells, Molecules, and Diseases > 2017 > 63 > C > 15-20

GNPAT p.D519G positivity is significantly increased in HFE p.C282Y homozygotes with markedly increased iron stores. We sought to determine associations of p.D519G and iron-related variables with iron stores in p.C282Y homozygotes.We defined markedly increased iron stores as serum ferritin >2247pmol/L (>1000μg/L) and either hepatic iron >236μmol/g dry weight or iron >10g by induction phlebotomy...

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Gordon D. McLaren, James C. Barton, Grant A. Ramm, Mary J. Emond, more

Hepatology > 65 > 3 > 1072 - 1073

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Population Screening for Hereditary Haemochromatosis in Australia: Construction and Validation of a State-Transition Cost-Effectiveness Model

Barbara Graaff, Lei Si, Amanda L. Neil, Kwang Chien Yee, more

PharmacoEconomics - Open > 2017 > 1 > 1 > 37-51

Introduction HFE-associated haemochromatosis, the most common monogenic disorder amongst populations of northern European ancestry, is characterised by iron overload. Excess iron is stored in parenchymal tissues, leading to morbidity and mortality. Population screening programmes are likely to improve early diagnosis, thereby decreasing associated disease. Our aim was to develop and validate a health...

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Christine E. McLaren, James C. Barton, V. Nathan Subramaniam, Grant A. Ramm, more

Hepatology > 63 > 6 > 2058 - 2060

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Christine E. McLaren, James C. Barton, Pradyumna D. Phatak, Mary J. Emond, more

Hepatology > 63 > 6 > 2056 - 2057

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Compound heterozygous FXN mutations and clinical outcome in friedreich ataxia

Charles A. Galea, Aamira Huq, Paul J. Lockhart, Geneieve Tai, more

Annals of Neurology > 79 > 3 > 485 - 495

Objective Friedreich ataxia (FRDA) is an inherited neurodegenerative disease characterized by ataxia and cardiomyopathy. Homozygous GAA trinucleotide repeat expansions in the first intron of FXN occur in 96% of affected individuals and reduce frataxin expression. Remaining individuals are compound heterozygous for a GAA expansion and a FXN point/insertion/deletion mutation. We examined disease‐causing...

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Polymorphisms affecting vitamin D–binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy

Jennifer J. Koplin, Noor H.A. Suaini, Peter Vuillermin, Justine A. Ellis, more

Journal of Allergy and Clinical Immunology > 2016 > 137 > 2 > 500-506.e4

There is evolving evidence that vitamin D insufficiency may contribute to food allergy, but findings vary between populations. Lower vitamin D–binding protein (DBP) levels increase the biological availability of serum vitamin D. Genetic polymorphisms explain almost 80% of the variation in binding protein levels.We sought to investigate whether polymorphisms that lower the DBP could compensate for...

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Christine E. McLaren, Mary J. Emond, V. Nathan Subramaniam, Pradyumna D. Phatak, more

Hepatology > 62 > 6 > 1918 - 1919

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Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload

Christine E. McLaren, Mary J. Emond, V. Nathan Subramaniam, Pradyumna D. Phatak, more

Hepatology > 62 > 2 > 429 - 439

To identify polymorphisms associated with variability of iron overload severity in HFE‐associated hemochromatosis, we performed exome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (n = 22; cases) or with normal or mildly increased iron stores (n = 13; controls). The 35 participants, residents of the United States, Canada, and Australia, reported no...

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INFONA - science communication portal

Search results for: Lyle C. Gurrin

Adiposity and estrogen receptor‐positive, postmenopausal breast cancer risk: Quantification of the mediating effects of fasting insulin and free estradiol

Effect decomposition through multiple causally nonordered mediators in the presence of exposure‐induced mediator‐outcome confounding

Early‐life exposure to sibling modifies the relationship between CD14 polymorphisms and allergic sensitization

Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNuts

Childhood measles contributes to post‐bronchodilator airflow obstruction in middle‐aged adults: A cohort study

Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review

Prevalence of clinic-defined food allergy in early adolescence: The SchoolNuts study

The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up

Age at onset and persistence of eczema are related to subsequent risk of asthma and hay fever from birth to 18 years of age

Peanut Allergen Threshold Study (PATS): Novel single-dose oral food challenge study to validate eliciting doses in children with peanut allergy

HFE p.C282Y homozygosity predisposes to rapid serum ferritin rise after menopause: A genotype‐stratified cohort study of hemochromatosis in Australian women

GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes

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Population Screening for Hereditary Haemochromatosis in Australia: Construction and Validation of a State-Transition Cost-Effectiveness Model

Reply

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Compound heterozygous FXN mutations and clinical outcome in friedreich ataxia

Polymorphisms affecting vitamin D–binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy

Reply

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload

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