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Key points
The pparab subtype in zebrafish is much more highly expressed in tissues with high oxidative activity than pparaa.
The pparab deficiency in zebrafish reduces fatty acid β‐oxidation both in liver and muscle, illustrating its functional homology as a mammalian peroxisome proliferator‐activated receptor α (PPARα).
pparab deficiency promotes metabolic reprogramming by increasing glucose utilization...
In article number 1907690, Sijie Lin and co‐workers investigate the environmental hazard potential of nano‐photocatalysts, TiO2 and g‐C3N4 using the model organism zebrafish. With light irradiation, nano‐photocatalysts produce detrimental reactive oxygen species that would only exert adverse effects upon close nano‐bio interactions. The toxicity outcome is greatly influenced by light energy, water...
Nano‐photocatalysts are known for their ability to degrade pollutants or perform water splitting catalyzed by light. Being the key functional ingredients of current and future products, the potential of nano‐photocatalysts releasing into the environment and causing unintended harm to living organisms warrants investigation. Risk assessment of these materials serves as an important step to allow safe...
Polychlorinated biphenyl (PCB) has been reported to have detrimental effects on retinal development. In order to explore the role of Shh signaling in retinal development after PCB1254 exposure in vivo and in vitro, zebrafish and RGC‐5 retinal cell line were used. Compared with the controls, PCB exposure inhibited proliferation and increased the apoptosis levels. The expression of Shh mRNA decreased...
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