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Background
Autophagy is a lysosomal degradation pathway that is essential for cell survival, differentiation, and homeostasis. This study aimed to investigate the contribution of autophagy to the pathogenesis of CRS with nasal polyps (CRSwNP).
Methods
The expression of autophagic proteins [microtubule‐associated protein 1 light chain 3B (LC3B)‐II, autophagy‐related proteins (Atg), and Beclin 1],...
BackgroundMucociliary dysfunction is a prominent pathophysiological feature of chronic rhinosinusitis with nasal polyps (CRSwNP); however, the precise mechanisms underlying mucociliary dysfunction are still unclear.
ObjectiveThe aim of this study was therefore to evaluate the effects of IFN‐γ, IL‐13, and IL‐17 on human nasal mucociliary differentiation and ciliary beat frequency (CBF) in patients...
Host immune responses must be tightly regulated by an intricate balance between positive and negative signals while fighting pathogens; persistent pathogens may usurp these regulatory mechanisms to dampen host immunity to facilitate survival in vivo. Here we report that Tim‐3, a negative signalling molecule expressed on monocytes and T cells, is up‐regulated on natural killer (NK) cells in individuals...
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