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Purpose To evaluate the effects of the antiepileptic medication vigabatrin (VGB) on the retina of pigmented rats. Methods Scotopic and photopic electroretinograms were recorded from dark- and light-adapted Long-Evans (pigmented) and Sprague Dawley (albino) rats administered, daily, 52–55 injections of 250 mg·kg−1·day−1 VGB or 25–26 injections of 500 mg·kg−1·day−1 VGB, or a corresponding number...
Purpose The purpose of this study was to identify the genes, biochemical signaling pathways, and biological themes involved in the pathogenesis of retinopathy of prematurity (ROP). Methods Next-generation sequencing (NGS) was performed on the RNA transcriptome of rats with the Penn et al. (Pediatr Res 36:724–731, 1994) oxygen-induced retinopathy model of ROP at the height of vascular abnormality,...
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