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First‐pass hepatic metabolism can significantly limit oral drug bioavailability. Drug transport from the intestine through the lymphatic system, rather than the portal vein, circumvents first‐pass metabolism. However, the majority of drugs do not have the requisite physicochemical properties to facilitate lymphatic access. Herein, we describe a prodrug strategy that promotes selective transport through...
Propharmaka In der Zuschrift auf S. 13904 ff. demonstrieren J. S. Simpson, C. J. H. Porter et al. eine Verbesserung der oralen Bioverfügbarkeit von Testosteron durch Synthese Glycerid‐basierter Propharmaka, die die Wirkstoff‐Freisetzung fördern und die Wirkstoffe zum lymphatischen System leiten.
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