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The kisspeptins are critical regulators of mammalian reproduction. Kisspeptin-10 ( 45 YNWNSFGLRF-NH 254 , kisspeptin-112–121 or metastin 45–54, NSC 741805), an active fragment of kisspeptin, has been shown to be a potent stimulator of gonadotropin-releasing hormone and secretion of luteinizing hormone in both rodents and primates. This shorter peptide fragment may have clinical...
A highly sensitive and specific LC‐MS/MS assay was developed and validated to quantify nevirapine (NVP) and its five metabolites [2‐, 3‐, 8‐, 12‐hydroxyl NVP (OHNVP) and 4‐carboxyl NVP (CANVP)] simultaneously in baboon serum and the assay was used to characterize their pharmacokinetic studies of an oral‐dose escalation study in baboon. The lower limit of quantification (LLOQ) for NVP and its four...
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