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We studied the effect of chemical sympathectomy by 6-hydroxydopamine (6-OHDA) on pain behavior and α 2 -adrenergic antinociception in rats with a spinal nerve ligation-induced neuropathy. For assessment of α 2 -adrenergic antinociception, the rats were treated systemically with two α 2 -adrenoceptor agonists, one of which only poorly (MPV-2426) and the other very well (dexmedetomidine)...
We determined whether chronic neuropathy changes response properties of neurons in the rostroventromedial medulla of rats, and whether (d-Tyr)L(Me-Phe)QPQRF-amide, a neuropeptide FF analogue, in the periaqueductal gray produces changes in responses of rostroventromedial medullary neurons that might underlie its antiallodynic effect described earlier. Single unit recordings of medullary neurons were...
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