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Objective
The objectives of this study were to investigate the effect of age on pharmacokinetic parameters of lamotrigine (LTG) and estimate parameter variability.
Methods
Patients (>18 years old) who were already on a steady‐state dose of LTG therapy with no interacting comedications were enrolled. Patients with significant cardiac disease, severe kidney dysfunction, or moderate‐to‐severe liver...
PurposeAlthough topiramate is widely prescribed for epilepsy and migraine, there is no intravenous product. We have developed an injectable topiramate formulation in which the drug is solubilized in a cyclodextrin matrix, Captisol® (Ligand Pharmaceuticals, Inc., La Jolla, CA). Our long‐term goal is to evaluate intravenous topiramate for the treatment of neonatal seizures. Prior to studies in newborns,...
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