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Introduction Outcome predictors in use today are prognostic only for hormone receptor-positive (HRpos) breast cancer. Although microarray-derived multigene predictors of hormone receptor-negative (HRneg) and/or triple negative (Tneg) breast cancer recurrence risk are emerging, to date none have been transferred to clinically suitable assay platforms (for example, RT-PCR) or validated against formalin-fixed...
Comparative genomic hybridization (CGH) is a rapid method for surveying the entire genome for increases or decreases in DNA copy number. In CGH, tumor and normal genomic DNA are labeled with two different fluorochromes and hybridized to normal metaphase chromosomes. Variations in the normalized ratio of fluorescence intensities correspond to regions of relatively increased or decreased copy number...
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