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Introduction
Fibroblast growth factor 10 (FGF10) is a signaling molecule with a well‐established role for lung branching morphogenesis. Rare heterozygous, deleterious variants in the FGF10 gene are known causes of the lacrimo‐auriculo‐dento‐digital (LADD) syndrome and aplasia of lacrimal and salivary glands. Previous studies indicate that pathogenic variants in FGF10 can cause childhood Interstitial...
Purpose
To determine optimal constrained tissue parameters and off‐resonance sequence parameters for single‐point macromolecular proton fraction (SP‐MPF) mapping based on a comprehensive quantitative magnetization transfer (qMT) protocol in healthy and demyelinated living mice at 7T.
Methods
Using 3D spoiled gradient echo‐based sequences, a comprehensive qMT protocol is performed by sampling the...
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