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The reference region model (RRM) for dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) provides pharmacokinetic parameters without requiring the arterial input function. A limitation of the RRM is that it assumes that the blood plasma volume in the tissue of interest is zero, but this is often not true in highly vascularized tissues, such as some tumours. This study proposes an extended...
Purpose
Reference region models (RRMs) can quantify tumor perfusion in dynamic contrast‐enhanced MRI without an arterial input function. Inspection of the RRM reveals that one of the free parameters in the fit is uniquely linked to the reference region and is common to all voxels. A two‐step approach is proposed that takes this constraint into account.
Methods
Three constrained RRM (CRRM) approaches...
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