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The eight congeners of vitamin E differ in their methylation pattern and either possess an alkyl (tocopherols, T) or an isoprenoid (tocotrienols, T3) side chain. The different chemical structures influence the biological activity of the vitamin, like the binding to the nuclear pregnane X receptor (PXR). P-glycoprotein (P-gp), a PXR target gene, is an efflux transporter expressed at various barriers...
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