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The synthetic dipeptides alanyl-glutamine (Ala-Gln) and glycyl-glutamine (Gly-Gln) are used as Gln substitution to provide energy source in the gastrointestinal tract due to their high solubility and stability. This study aimed to investigate the effects of Gln, Ala-Gln and Gly-Gln on mitochondrial respiration and protein turnover of enterocytes. Intestinal porcine epithelial cells (IPEC-J2) were...
ScopeGlutamine supplementation enhances secretory IgA (SIgA) production in the intestine, but the mechanism is largely unknown. We examined this issue using a mouse model.
Methods and ResultsIn mouse model, glutamine supplementation increased both SIgA abundance in intestinal luminal contents and IgA+ plasma cell numbers in the mouse ileum, and decreased bacterial loads in mouse mesenteric lymph...
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