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Tumor necrosis factor α (TNFα) is involved in fumonisin-induced hepatotoxic effects in mice. The hepatic response to fumonisin B 1 (FB 1 ) was reduced in transgenic animals lacking either of the two TNFα receptors. In the present study, we hypothesized that the effect of a similar fumonisin treatment in animals lacking either TNFα or both TNFα receptors would be considerably less than...
Fumonisins are fungal metabolites and suspected human carcinogens. They inhibit ceramide synthase in vitro, enhance tumor necrosis factor α (TNFα) production, and cause apoptosis. Fumonisin B 1 (FB 1 ) was fed to rats and mice for 2 years or, in separate studies, given to rats or mice for up to 4 weeks. Kidney tubule adenomas and carcinomas were found in male rats fed =<50ppm, whereas...
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