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The solvent toluene has neurotoxic properties that are especially relevant in the working environment. Short-term exposure limits (STELs) vary from 50ppm up to 300ppm across countries but their acute effects remain elusive in humans. Several in vitro and in vivo studies elucidated that toluene acutely acts by perturbations of different neurotransmitter systems. More specifically visual evoked potentials...
Objective. There are findings of cross-sectional studies on slight cognitive effects due to toluene exposure below 50ppm. The critical points of the earlier studies will be scrutinised by a follow-up study with four examinations in 5 years. Methods. Employees from 14 magazine rotary printing plants were classified into groups of high (printing area) vs low (end-processing) and short vs long exposure...
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