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Human bladder cancer may be caused by exposure to aromatic amines. The polymorphic enzyme N-acetyltransferase 2 (NAT2) is involved in the metabolism of these compounds. Two classical studies on chemical workers in Europe, exposed in the past to aromatic amines like benzidine, unambiguously showed that the slow acetylator status is a genetic risk factor for arylamine-induced bladder cancer. In the...
The purpose of this study was to evaluate the impact of polymorphism of enzymes involved in metabolism of aromatic amines (N-acetyltransferase 2, NAT2) and polycyclic aromatic hydrocarbons (glutathione-S-transferase μ, GSTM1) in urothelial bladder cancer patients in an area of former coal, iron and steel industries.179 patients were phenotyped for NAT2 by HPLC according to their excretion of caffeine...
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