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We once reported that P‐glycoprotein (P‐GP) and multidrug resistance‐associated protein 2 (MRP2) were oppositely regulated at the blood–brain barrier (BBB) of thioacetamide‐induced acute liver failure (ALF) rats. This study aimed to investigate whether ALF affected function and expression of breast cancer‐resistant protein (BCRP) at the BBB of rats and the role of ammonia in the regulation. ALF rats...
Ammonia is considered to be the main neurotoxin responsible for hepatic encephalopathy resulting from liver failure. Liver failure has been reported to alter expression and activity of P‐glycoprotein (P‐gp) and multidrug resistance‐associated protein 2 (Mrp2) at the blood–brain barrier (BBB). The aim of this study was to investigate whether ammonia is involved in abnormalities of expression and activity...
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