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Dysregulation of adenosine 2A (A 2A ) receptor function in brain has been implicated in multiple psychiatric and neurodegenerative disorders, including schizophrenia and Parkinson's disease, making the development of an imaging agent to study A 2A receptors in both healthy brain and disease states desirable. In this study, [ 123 I]MNI-420 was evaluated as a potential single...
This study aims to investigate the pharmacokinetics of a recently developed radiotracer for imaging of the norepinephrine transporter (NET) in baboon brain, 123I‐INER, using single photon emission computed tomography (SPECT). In addition, it also aims to determine NET occupancy by atomoxetine and reboxetine, two selective norepinephrine reuptake inhibitors, using 123I‐INER in baboons. Baseline and...
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