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Truncation is a statistical phenomenon that occurs in many time‐to‐event studies. For example, autopsy‐confirmed studies of neurodegenerative diseases are subject to an inherent left and right truncation, also known as double truncation. When the goal is to study the effect of risk factors on survival, the standard Cox regression model cannot be used when the survival time is subject to truncation...
Neurodegenerative diseases require an autopsy for confirmation of diagnosis. When death is the event of interest, studies based on autopsy‐confirmed diagnoses result in right truncated survival times because individuals who live past the end of study date do not receive a pathological diagnosis and are therefore not included in the sample. Furthermore, many studies of neurodegenerative diseases recruit...
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