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Background
Neurofilament light chain protein (NfL) is a promising biomarker of neurodegeneration.
Objectives
To determine whether plasma and CSF NfL (1) associate with motor or cognitive status in Parkinson's disease (PD) and (2) predict future motor or cognitive decline in PD.
Methods
Six hundred and fifteen participants with neurodegenerative diseases, including 152 PD and 200 healthy control...
Biomarkers are often measured with error due to imperfect lab conditions or temporal variability within subjects. Using an internal reliability sample of the biomarker, we develop a parametric bias‐correction approach for estimating a variety of diagnostic performance measures including sensitivity, specificity, the Youden index with its associated optimal cut‐point, positive and negative predictive...
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