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Rosuvastatin, a novel potent HMG-CoA reductase inhibitor, is excreted into bile mediated by breast cancer resistance protein (BCRP). Our objective was to determine the association between the most frequent single nucleotide polymorphisms (SNPs) of the BCRP (421C>A) and the pharmacokinetics of rosuvastatin.Pre-screening of SLCO1B1 521TC and CYP2C9 ⁎ 1/ ⁎ 3 were performed before this...
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