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Background. Oxaliplatin and topotecan are novel options for a variety of neoplasms. Topotecan has shown fewer side effects and higher efficacy when given as a continuous i.v. infusion compared to single doses, but this regimen has not yet been combined with oxaliplatin. Patients and methods. This phase I/II trial was designed to establish the dose-limiting toxicity of a combination of oxaliplatin...
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